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Characterization of deletions of chromosome 7 short arm occurring as primary karyotypic anomaly in acute myeloid leukaemia
Author(s) -
Mecucci Cristina,
Van Orshoven Angeline,
Boogaerts Marc,
Michaux JeanLouis,
Van den Berghe Herman
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb06267.x
Subject(s) - karyotype , malignancy , chromosome , myeloid , myelodysplastic syndromes , biology , myeloid leukaemia , bone marrow , cytogenetics , pathology , cancer research , medicine , genetics , gene
Summary Three patients with an acute myeloid leukaemia (AML) showed a deletion of the short arm of chromosome 7 with loss of the deleted material. The 7p — anomaly originated from either a terminal or an interstitial deletion and it represented the only karyotypic aberration in all the three cases. According to the clinical, morphological and immunological features of this series of patients, a 7p — chromosome appears to be associated with a group of AML with myelodysplastic features in the bone marrow, including secondary disorders in patients treated for a previous malignancy.