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Familial hypofibrinolysis and venous thrombosis
Author(s) -
Petäjä Jari,
Rasi Vesa,
Myllyla Gunnar,
Vahtera Elina,
Hallman Heikki
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb04297.x
Subject(s) - venous thrombosis , medicine , thrombosis , cardiology
Summary Nine patients with, and 11 without, venous thromboses (DVT) from two families were studied. In family 1, four members with, and one without. DVT had t‐PA activity below the lower limit of the controls (21.3 IU/ml, n= 19) after 20 min venous occlusion (VO). After VO t‐PA antigen (t‐PA:Ag) was below the lowest value of the controls (22.8 ng/ml) in all five cases with low t‐PA activity. All the family members, both with and without thrombosis, had normal t‐PA inhibitor activities (PAI). In family 2 t‐PA activity after VO was low in three symptomatic and four asymptomatic family members. t‐PA : Ag was also low in four of these. PAI level was normal in all but one family member. Mild type I von Willebrand's disease was discovered in four members of family 2. Deficient t‐PA : Ag response was found in two of these. Antithrombin III, protein C and protein S were normal in both families. It is concluded that low fibrinolytic capacity, independent of PAI, is associated with familial DVT. Our data suggests autosomal dominant inheritance.