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Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti‐PI A1 specificity: evidence for a host‐derived immune reaction
Author(s) -
Panzer Simon,
Kiefel Volker,
Bartram Claus R.,
Haas Oskar A.,
Hinterberger Wolfgang,
MuellerEckhardt Christian,
Lechner Klaus
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb04264.x
Subject(s) - immunology , platelet , antibody , transplantation , immune system , antigen , human leukocyte antigen , isoantibodies , medicine , biology
Summary We report on a male patient transplanted from his HLA‐matched sister for Ph 1 ‐chromosome positive chronic myelogenous leukaemia who developed immune thrombocytopenia more than 1 year after transplantation. The platelet antibody reacted with the platelet specific antigen PI A1 on donor platelets, and also on recipient platelets after engraftment. A presumed host‐versus‐donor induced thrombocytopenia was supported by Southern blot analysis using a Y‐chromosome specific probe demonstrating residual hostorigin cells in the patient's excised spleen.