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Hairy cell leukaemia: observations on natural killer activity in different clinical stages of the disease
Author(s) -
Demeter J.,
Paloaczi K.,
Lehoczky D.,
Benczuar M.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb04261.x
Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , k562 cells , natural killer cell , immunology , disease , stage (stratigraphy) , antibody , biology , in vitro , cancer research , medicine , leukemia , biochemistry , paleontology
Summary Follow‐up studies of natural killer (NK) cells, NK activity and antibody dependent cellular cytotoxicity (ADCC) in the course of hairy cell leukaemia (HCL) were carried out in a series of patients affected by the disease. NK activity against K562 targets was found to be high in all the patients with non‐symptomatic stable disease. On the other hand, absent or extremely low NK activity was found only in patients with symptomatic progressive disease. NK activity determined in the transitional stages showed values between these two extremes. Antibody dependent cellular cytotoxicity (ADCC) was less closely correlated with the clinical stage than NK activity. Our findings suggest that investigation of in vitro NK cell cytotoxicity might serve as a useful adjunct in determining clinical stage in HCL.