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CD1 expression on B‐CLL lymphocytes
Author(s) -
MerleBeral Héalégne,
Boumsell Laurence,
Michel Ariane,
Debréa Patrice
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb04256.x
Subject(s) - monoclonal antibody , antigen , flow cytometry , biology , antibody , epitope , cd1 , b cell , microbiology and biotechnology , immunology , natural killer t cell , cd8
Summary In a previous report we showed that D47 CD1a monoclonal antibody positively labelled B‐CLL cells of some patients. Six cases were selected to further characterize CD1 antigenic expression at the leukaemic cell surface using flow cytometry with a battery of six CD1a, two CD1b and two CD1c monoclonal antibodies. CLL cells were positively labelled with CD1a antibodies except OKT6 and NA1/34: in all cases they were CD1b negative and CD1c positive. These results suggested that CD1a, c epitopes can be detected on leukaemic B cells in addition to other T cell differentiation antigens. In view of recently published data demonstrating the presence of CD1c molecule in normal B cell subsets, our results further question the relationship of B‐CLL with a restricted subpopulation of B cells.