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IL‐2 and myelopoiesis: IL‐2 induces blast cell proliferation in some cases of acute myeloid leukaemia
Author(s) -
Carron J. A.,
Cawley J. C.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb00248.x
Subject(s) - myelopoiesis , myeloid , immunology , colony stimulating factor , interleukin 3 , granulocyte macrophage colony stimulating factor , myeloid leukemia , myeloid leukaemia , biology , precursor cell , cancer research , medicine , cell , haematopoiesis , t cell , cytokine , microbiology and biotechnology , stem cell , immune system , interleukin 21 , biochemistry
Summary Interleukin‐2 (IL‐2) stimulated H‐thymidine incorporation in the blasts of six of 21 cases of acute myeloid leukaemia (AML). An IL‐2 induced increase in cell numbers was directly demonstrated in the two patients studied in this way, and T‐cell contamination was rigorously excluded. The IL‐2‐induced proliferation was usually less marked than that caused by granulocyte‐macrophage colony stimulating factor (GM‐CSF), and IL‐2 moderately enhanced GM‐CSF‐induced stimulation in five of the six patients; in the sixth, IL‐2 and GM‐CSF were strongly synergistic. IL‐2‐induced proliferation was observed only in AML with a monocytic component (M4/M5), but not all M4/M5 leukaemias responded to IL‐2. There was no correlation between expression of the light‐chain of the IL‐2 receptor and IL‐2‐induced stimulation. It is suggested that IL‐2 is involved at a restricted stage of early myelopoiesis, perhaps when cells are becoming committed to the monocytic lineage: and that IL‐2 is a growth factor for early myeloid cells in a proportion of cases of AML.