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More familial leukaemia in ALL patients with both unexplained high transcortin levels and an HLA antigen Cw3
Author(s) -
Moor P.,
Boogaerts M.,
Louwagie A.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb07626.x
Subject(s) - medicine , human leukocyte antigen , antigen , lymphoma , immunology
Summary. In a group of 74 adult ALL patients 25 had a transcortin level ±3 SD above the normal mean, 15 expressed an HLA‐Cw3 antigen and 11 combined both characteristics. In this subgroup of 11 ALL patients, five had familial leukaemia, i.e. at least one relative with acute leukaemia or lymphoma. On the other hand, only three examples of familial leukaemia were found in a series of 59 ALL patients with one or none of these two characteristics (relative risk: 15.6; P <0.001).