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Distribution of the CD45R antigen in the maturation of lymphoid and myeloid series: the CD45R negative phenotype is a constant finding in T CD4 positive lymphoproliferative disorders
Author(s) -
Huelin C.,
Gonzalez M.,
Pedrinaci S.,
Higuera B.,
Piris M. A.,
Miguel J. San,
RuizCabello F.,
Garrido F.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb07619.x
Subject(s) - myeloid , antigen , immunology , lymphoproliferative disorders , cd8 , biology , haematopoiesis , t lymphocyte , myelopoiesis , phenotype , lymphoproliferative response , lymphoma , in vitro , stem cell , microbiology and biotechnology , peripheral blood mononuclear cell , genetics , gene
Summary. We have compared the expression of the common leucocyte antigen (CD45) and the restricted leucocyte antigen (CD45R) on normal haematopoietic cells, cell lines, and a total number of 136 cases of myeloid and lymphoid proliferative syndromes. CD45, the conventional leucocyte antigen, presents a generalized distribution along the lymphoid and myeloid maturation pathway with the exception of some myelomas and pre‐B leukaemias. In contrast, the expression of the CD45R determinant is more limited. Although it is found in the majority of the differentiation stages of B cells and monocytes, it is present only in the early stages of myeloid differentiation. On T cells it is expressed on mature thymocytes and in the majority of CD8+ lymphocytes and a subset of CD4+ cells on peripheral blood. Finally, our results also indicated that CD4+ T lymphoproliferative syndromes are derived from the CD4+ CD45R‐ subset (20/20 cases).