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Presence of an inhibitor of glycosyltransferase activity in a patient following an ABO incompatible liver transplant
Author(s) -
Barbolla L.,
Mojena M.,
Cienfuegos J. A.,
Escartín P.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb07608.x
Subject(s) - abo blood group system , glycosyltransferase , transferase , sephadex , liver transplantation , antibody , transplantation , chemistry , biochemistry , enzyme , medicine , endocrinology , biology , immunology
Summary. The contribution of the liver to plasma ABO glycosyltransferase activity has been studied in a group O individual transplanted with a liver from a group B donor. The B transferase activity present in the post‐transplantation plasma was negligible. However, a potent B transferase inhibitor, absent from the pretransplantation plasma, was present after transplantation. The inhibitor was present in the excluded fraction following Sephadex G‐25 gel filtration, but was retained by a protein A‐Sepharose column, suggesting that it was an IgG antibody. This inhibitor was also effective in reducing A transferase activity.