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Postnatal changes in plasma burst‐promoting activity (BPA) levels in preterm infants
Author(s) -
Iwai Yoshitaka,
Nakato Hidekazu,
Kim KwangMyong,
Tanaka Mayumi,
Yoshimura Tomohide,
Mayumi Mitsufumi,
Mikawa Haruki
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb07594.x
Subject(s) - erythropoiesis , erythropoietin , endocrinology , medicine , plasma levels , plasma concentration , physiology , anemia
Summary. Two‐stage cell culture assays were used to determine burst‐promoting activity (BPA) levels in the plasma of untransfused premature infants during the early anaemic period. The plasma BPA levels decreased during the early phase of the postnatal fall in haemoglobin and the mean plasma BPA levels at 2 and 4 weeks of age were significantly lower (24 ± 9% and 20 ± 14%) than those of normal adults (53 ± 17%). After 8 weeks of age, plasma BPA levels increased markedly in correlation with the recovery of erythropoiesis. Inhibitors of erythroid colony growth were not significantly elevated in the plasma of premature infants. These results suggest that BPA may act as a regulator of erythropoiesis in preterm infants along with erythropoietin.