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Two different theta (θ) globin gene deletions observed among black newborn babies
Author(s) -
Fei Y. J.,
Fujita S.,
Huisman T. H. J.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb06197.x
Subject(s) - gene , genetics , globin , biology , gene cluster , dna , population , microbiology and biotechnology , medicine , environmental health
Summary Two different θ 1 globin gene deletions have been detected in the Black population of the southeastern U.S.A. Restriction mapping of the α globin gene cluster indicated that one deletion removes ∼ 1.8 kb of DNA including most of the θ 1 globin gene, while the second removes ∼ 6 kb of DNA including the entire θ 1 globin gene. These defects do not cause haematological alterations in the newborn or in the adult (established for the smaller deletion only), nor were changes observed in polypeptide chain patterns at birth.