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Alkaline phosphatase positive precursors of adipocytes in the human bone marrow
Author(s) -
Bianco P.,
Costantini M.,
Dearden L. C.,
Bonucci E.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb04225.x
Subject(s) - alkaline phosphatase , bone marrow , reticular connective tissue , reticular cell , cytochemistry , chemistry , pathology , endocrinology , medicine , biology , enzyme , biochemistry , spleen
Summary Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane‐bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of ‘reticular’cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.