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Prognostic features of chronic myelomonocytic leukaemia: a modified Bournemouth score gives the best prediction of survival
Author(s) -
Worsley A.,
Oscier D. G.,
Stevens J.,
Darlow S.,
Figes Ann,
Mufti G. J.,
Hamblin T. J.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb04173.x
Subject(s) - medicine , chronic myelomonocytic leukemia , gastroenterology , refractory (planetary science) , monocyte , bone marrow , platelet , monocytosis , overall survival , myelodysplastic syndromes , biology , astrobiology
Summary. We have studied the clinical and laboratory features of 53 cases of chronic myelomonocytic leukaemia (CMML) defined according to the FAB criteria. A granulocyte count of < 16 x 10 9 /l or a monocyte count of < 2.6 x 10 9 /l correlated with a poorer survival, but the best predictor of poor survival was the modified ‘Bournemouth’ score in which one point each was allocated for Hb < 10 g/dl, neutrophils < 2.5 x 10 9 /l or > 16 x 10 9 /l, platelets < 100 x 10 9 /l and bone marrow blasts > 5%. A score of 2 or more was predictive of poor survival (Chi 2 = 10.25; P < 0.001). Those patients with low monocyte and neutrophil counts and a low modified Bournemouth score tended to have a clinical course similar to refractory anaemia (RA) with an indolent course not requiring treatment and long survival whereas those with high monocyte and neutrophil counts and a high modified ‘Bournemouth’ score have a clinical course resembling that of refractory anaemia with excess of blasts (RAEB).