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Phenotypic and functional T cell subset abnormalities in patients with aplastic anaemia and hypogammaglobulinaemia
Author(s) -
Raziuddin Syed,
Sheikha Anwar K. I.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb02483.x
Subject(s) - phytohaemagglutinin , immunology , cytotoxic t cell , t cell , pokeweed mitogen , cd8 , biology , concanavalin a , lymphokine , antigen , immune system , in vitro , biochemistry
We have investigated T cell abnormalities present in blood of two patients with aplastic anaemia and hypogammaglobulinaemia. There was a marked increase in class II. major histocompatibility complex, HLA‐DR+ antigen, and interleukin‐2 receptor (Tac+) bearing CD4+ helper/inducer T cells, and a concurrent reduction of CD8+ suppressor/cytotoxic T cells. These CD4+ T cells produced an elevated proliferative response to phytohaemagglutinin and concanavalin A. Interestingly, the T cell subset mainly responsible for elevated production of the lymphokine, interkeukin‐2, under the stimulus of phytohaemagglutinin, was characterized as belonging to a CD4+ T cell subset. Functional studies, using a pokeweed mitogen driven IgG, IgA and IgM synthesis, demonstrated a correlation between CD4+ T cell deficient helper function for B cell differentiation and the clinical finding of the patient's hypogammaglobulinaemia.