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Terminal deoxynucleotidyl transferase and HLA‐DR expression appear unrelated to prognosis of acute myeloid leukaemia
Author(s) -
Swirsky D. M.,
Greaves M. F.,
Gray R. G.,
Rees J. K. H.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb02463.x
Subject(s) - terminal deoxynucleotidyl transferase , medicine , bone marrow , myeloid , peripheral blood mononuclear cell , myeloid leukaemia , immunology , hla dr , chemotherapy , leukemia , gastroenterology , antigen , tunel assay , biology , immunohistochemistry , biochemistry , in vitro
Mononuclear cells from peripheral blood or bone marrow from 314 patients with acute myeloid leukaemia were examined for the presence of nuclear terminal deoxynucleotidyl transferase (304 patients), surface membrane expression of HLA‐DR (314 patients) and the common acute lymphoblastic leukaemia antigen (281 patients). All patients were treated with identical remission induction chemotherapy, and morphological diagnosis was carried out in a central laboratory. The overall complete remission rate was 70%. There were no significant correlations between the immunological markers and complete remission rate, duration of remission, or survival.