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Inhibition of bone marrow myelopoiesis and erythropoiesis in vitro by anti‐retroviral nucleoside derivatives
Author(s) -
Johnson Margaret,
Caiazzo Teresa,
Molina JeanMichel,
Donahue Robert,
Groopman Jerome
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb02454.x
Subject(s) - erythropoiesis , myelopoiesis , in vitro , bone marrow , nucleoside , medicine , cancer research , ineffective erythropoiesis , pharmacology , chemistry , immunology , biology , biochemistry , haematopoiesis , microbiology and biotechnology , anemia , stem cell
We have studied the in vitro effects of nucleoside inhibitors of reverse transcriptase on bone marrow myeloid and erythroid progenitor development. Both 3′‐azido‐3′‐deoxythymidine (AZT) and 2′,3′‐dideoxycytidine (DDC) potently inhibited in vitro haematopoiesis, while 2′,3′‐di‐deoxyadenosine (DDA) was less inhibitory in this culture system. Studies of candidate antiretroviral agents in bone marrow culture may predict clinical toxicity as well as lead to strategies for combination therapy which minimize impairment of haematopoiesis.