Premium
Beneficial effect of intravenous gammaglobulin in a patient with complement‐mediated autoimmune thrombocytopenia due to IgM‐anti‐platelet antibodies
Author(s) -
Brand A.,
Witvliet M.,
Claas F. H. J.,
Eernisse J. G.
Publication year - 1988
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1988.tb02407.x
Subject(s) - platelet , autoantibody , medicine , immunology , gamma globulin , in vivo , antibody , purpura (gastropod) , thrombocytopenic purpura , complement system , autoimmune thrombocytopenia , biology , ecology , microbiology and biotechnology
Intravenous gammaglobulin (IV‐IgG) was administered to a patient with chronic idiopathic thrombocytopenic purpura due to an unusual IgM platelet autoantibody causing in vitro complement‐dependent thrombocytoxicity and in vivo intravascular platelet destruction. After IV‐IgG infusion the peripheral platelet count temporarily increased to normal values, the mean platelet survival time increased and the platelet sequestration pattern changed from intravascular to predominantly hepatic destruction. In vivo and in vitro observations in this patient illustrate a transient beneficial effect of gammaglobulin infusion due to interference with the complement‐fixing autoantibodies against platelets.