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The calcium permeability of cold‐stored erythrocytes
Author(s) -
McNamara M. K.,
Wiley J. S.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06930.x
Subject(s) - calcium , permeability (electromagnetism) , chemistry , blood preservation , intracellular , biophysics , cold storage , red blood cell , biochemistry , andrology , biology , membrane , medicine , organic chemistry , horticulture
Summary The calcium permeability of erythrocytes was studied by a new technique in which cells were loaded with an intracellular calcium chelator, quin 2, followed by measurement of 45 Ca influx. The erythrocyte calcium permeability did not change during cold storage of blood in citrate‐phosphate‐dextrose for 6 weeks. Previous reports of an increased Ca 2+ permeability in cold‐stored erythrocytes have been based on an ATP‐depletion technique which yields values for Ca 2+ influx which are influenced by erythrocyte 2.3DPG levels.