Premium
Depressed fibrinolysis in patients with acute leukaemia
Author(s) -
Guarini A.,
Mussoni L.,
Gugliotta L.,
Chetti L.,
Niewiarowski T.,
Catani L.,
Macchi S.,
Donati M. B.,
Tura S.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06918.x
Subject(s) - fibrinolysis , medicine , intensive care medicine
Summary The fibrinolytic system was studied in 46 patients with acute leukaemia at diagnosis. Untreated patients (with the sole exception of the M3 subgroup) showed an inhibition of fibrinolytic activity, measured by the euglobulin lysis time and area. This inhibition was accompanied by reduced t‐PA antigen and t‐PA inhibitor activity. No correlation was found between the above‐mentioned fibrinolytic parameters and the biochemical haematological values considered, nor with clinical and/or laboratory features of DIC. fever, liver failure. The decrease in immunological plasminogen and functional α 2 ‐antiplasmin, showed a significant correlation with the presence of clinical and/or laboratory signs of DIC, as diagnosed on the basis of concomitant increase in fibrin monomers, plasmatic fibrinopeptide A and serum FDP.