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A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia
Author(s) -
Heim Sverre,
Avanzi GianCarlo,
Billstroum Rolf,
Kristoffersson Ulf,
Mandahl Nils,
Bekassy Albert N.,
Garwicz Stanislaw,
Wiebe Thomas,
Pegoraro Loigi,
Falda Michele,
Resegotti Luigi,
Mitelman Felix
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06917.x
Subject(s) - chromosomal translocation , karyotype , bone marrow , chromosomal abnormality , thp1 cell line , acute monocytic leukemia , monocytic leukemia , abnormality , pathology , biology , cancer research , immunology , leukemia , medicine , chromosome , cell culture , genetics , gene , psychiatry
Summary The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re‐evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.