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Long survival in B‐CLL correlates with surface IgM K phenotype
Author(s) -
Hamblin T. J.,
Oscier D. G.,
Stevens J. R.,
Smith J. L.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06885.x
Subject(s) - medicine , stage (stratigraphy) , referral , lymphocyte , disease , gastroenterology , phenotype , immunology , pediatrics , biology , family medicine , paleontology , biochemistry , gene
Summary 200 patients with B‐cell chronic lymphocytic leukaemia (B‐CLL) presenting to a single centre over 13 years have been studied. In 72.2% the diagnosis was made on an incidental blood count, and 70.1% were stage A at presentation. Those patients whose cells expressed surface IgM K were significantly more likely to be stage A at presentation and significantly less likely to have a lymphocyte count >50x 10 9 /1, to have progressive disease or to require treatment than those with other classes of surface Ig. Patients whose cells express surface IgM K have a significantly longer actuarial survival than others and this is also so when only patients in Binet stage A or when only patients presenting below the age of 75 are studied. By studying all of the cases presenting in a single catchment area we have attempted to avoid the bias against trivial disease likely to be seen in specialist referral centres.