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Stromal stem cells (CFU‐f) in yolk sac, liver, spleen and bone marrow of pre‐ and postnatal mice
Author(s) -
Van Den Heuvel Rosette L.,
Versele Sigrid R. M.,
Schoeters Greet E. R.,
J. Vanderborght Oscar L.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06884.x
Subject(s) - spleen , bone marrow , yolk sac , haematopoiesis , stromal cell , stem cell , biology , population , andrology , pathology , immunology , medicine , microbiology and biotechnology , embryo , environmental health
Summary Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU‐f assay) occur which are correlated with haemopoiesis. (1) In the liver, spleen and bone marrow, high numbers of CFU‐f precede high haemo‐poietic stem cell values. (2) As haemopoiesis starts in the spleen. CFU‐f numbers in fetal liver are low. Similarly, CFU‐f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. (3) In spleen and bone marrow, CFU‐f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.