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Fluorouracil (5‐FU) induced acute immune haemolytic anaemia
Author(s) -
Sandvei P.,
Nordhagen R.,
Michaelsen T. E.,
Wolthuis K.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb06868.x
Subject(s) - medicine , haemolysis , coombs test , antibody , gastroenterology , immunology , drug , immune system , pharmacology
Summary. A female patient on Fluorouracil (5‐FU) therapy for rectal carcinoma developed acute intravascular haemolysis with her fifteenth drug injection; a similar episode occurred later after a controlled challenge with the drug. A 5‐FU‐dependent complement‐activating IgM antibody, which reacted with RBC in an indirect antiglobulin test, was detected in her serum. The antibody did not react with cord RBC, but a blood group specificity could not be determined. An excess of 5‐FU in the indirect antiglobulin tests resulted in inhibition of these reactions.