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Multiple molecular abnormalities in Ph 1 chromosome positive acute lymphoblastic leukaemia
Author(s) -
Dreazen Orna,
Klisak Ivana,
Jones Gary,
Ho Winston G.,
Sparkes Robert S.,
Gale Robert Peter
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb02353.x
Subject(s) - chromosomal translocation , abl , breakpoint cluster region , philadelphia chromosome , chromosome , chronic myelogenous leukemia , biology , cytogenetics , chromosome 22 , chromosome 9 , gene , cancer research , microbiology and biotechnology , genetics , leukemia , tyrosine kinase , receptor
Summary The Ph 1 chromosome is present in 95% of patients with chronic myelogenous leukaemia (CML). The Ph 1 chromosome also occurs in 5–25% of children and adults with acute lymphoblastic leukaemia (ALL). This observation raises questions as to whether these diseases are similar or identical. In patients with CML the c‐ abl and hcr genes are translocated and abnormally expressed. We studied molecular events related to bcr and c‐ abl in five patients with ALL to determine its relationship to CML. Four had the Ph 1 chromosome; the fifth a probable Ph 1 chromosome. c‐ abl and bcr abnormalities identical to CML were detected in four suggesting a common molecular basis. One patient with the Ph 1 chromosome and c‐ abl translocation lacked these molecular changes but had abnormal c‐ abl gene transcription apparently unrelated to her. These data suggest that Ph 1 chromosome positive ALL is heterogeneous; in some patients the molecular abnormality is identical to CML; in others c‐ abl is likewise involved but via a different mechanism.