Premium
Reduced risk of non‐A, non‐B hepatitis after a first exposure to ‘wet heated’factor VIII concentrate
Author(s) -
Kernoff P. B. A.,
Miller E. J.,
Savidge G. F.,
Machine S. J.,
Dewar M. S.,
Preston F. E.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb02328.x
Subject(s) - risk factor , medicine , hepatitis b
Summary The risk of post‐infusion non‐A, non‐B hepatitis (NANBH) in patients receiving a first exposure to unheated or conventionally ‘dry heated’factor VIII concentrates approaches 100%. implying invariable contamination of these products. Amongst 18 patients who received a first treatment with a ‘wet heated’commercial concentrate, five (28%) developed asymptomatic NANBH, suggesting a more efficient inactivation of NANB agent(s) by this process. 2/9 (22%) of the batches of concentrate used in the study were implicated in NANBH transmission. One of these two batches. responsible for NANBH in four patients, had been prepared from a plasma pool containing an unusually large proportion of donations with high alanine aminotransferase (ALT) levels. A resulting high level of viral contamination in this batch may have been sufficient to override the effects of the sterilization process. All patients remained anti‐HIV seronegative at 17–28 months of follow‐up.