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Abnormalities of chromosome 12p 13 and malignant proliferation of eosinophils: a nonrandom association
Author(s) -
Keene P.,
Mendelow B.,
Pinto M. R.,
Bezwoda W.,
MacDougall L.,
Falkson G.,
Ruff P.,
Bernstein R.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb02291.x
Subject(s) - eosinophil , eosinophilia , chromosome , pathology , malignancy , eosinophilic , chromosome 12 , immunology , medicine , biology , cancer research , genetics , gene , asthma
S ummary . Four patients representing a spectrum of haematological malignancies are reported. Two patients had Philadelphia chromosome negative myeloproliferative disorders, one had acute lymphoblastic leukaemia and one had eosinophilic leukaemia. In each case eosinophilia was present and demonstrated to be part of the malignancy by the association of clonally abnormal metaphases with eosinophil granules. Abnormalities involving the short arm of chromosome 12 (12p 13) were a constant feature in all four cases and therefore a nonrandom association between this chromosome region and malignant eosinophil proliferation is proposed.