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Simultaneously increased expression of the c‐myc and, mU chain genes in the acute blastic transformation of a chronic lymphocytic leukaemia
Author(s) -
Torelli Umberto L.,
Torelli Giuseppe M.,
Emilia Giovanni,
Selleri Licia,
Venturelli Donatella,
Artusi Tullio,
Donelli Amedea,
Colò Alessandro,
Fornieri Claudio
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb02259.x
Subject(s) - clone (java method) , myb , gene , blast crisis , microbiology and biotechnology , population , biology , northern blot , southern blot , chronic lymphocytic leukemia , gene expression , immunology , cancer research , leukemia , medicine , genetics , environmental health
S ummary . A B‐cell chronic lymphocytic leukaemia terminated, 5 years from the onset, with a blast crisis. Karyotype analysis showed that the terminal lymphoblastic population evolved from the original B lymphocytic clone. The levels of expression of several oncogenes, as well as the μ chain gene, were assayed by Northern blot hybridization analysis of RNA extracted from the lymphoid populations before and after the acute transformation'. A seven‐ to eight‐fold increase in the expression of c‐myc and p chain genes was observed in the blast population. c‐myb. c‐fes. c‐ t i a ras were not expressed either before or after the blastic transformation.