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A myeloproliferative disease in two infants associated with eosinophilia and chromosome t(1;5) translocation
Author(s) -
Darbyshire P. J.,
Shortland D.,
Swansbury G. J.,
Sadler J.,
Lawler S. D.,
Chessells J. M.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb01331.x
Subject(s) - chromosomal translocation , eosinophilia , monosomy , chromosome , abnormality , down syndrome , chromosome abnormality , medicine , immunology , genetics , biology , karyotype , pediatrics , gene , psychiatry
Summary Two children are described who presented at the age of 5 and 7 months with anaemia, a high white cell count with eosinophilia and thrombocytopenia. Both children had an identical balanced translocation t(1;5)(q23;q33) and no evidence of a constitutional abnormality. The response to treatment of one child was poor, the other remains well on therapy. This translocation has not been previously reported and is likely to represent a subclass of myeloproliferative disorder analogous to the monosomy 7 syndrome, although less common. The previous literature of acquired chromosome abnormalities involving chromosomes 1 and 5 is reviewed.