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Granulocyte antibodies in leukaemic chronic lymphoproliferative disorders
Author(s) -
Rustagi Pradip K.,
Han Tin,
Ziolkowski Lynn,
Farolino Deborah L.,
Currie Mark S.,
Logue L.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.tb01327.x
Subject(s) - lymphocytosis , medicine , chronic lymphocytic leukemia , lymphoproliferative disorders , immunology , granulocyte , antibody , pathology , leukemia , lymphoma
Summary The anti‐granulocyte activity of serum from patients with B‐cell chronic lymphocytic leukaemia (CLL) and other lymphoproliferative disorders was investigated. Granulocyte‐binding IgG was measured in 34 patients with CLL, 13 patients with hairy cell leukaemia, one patient with prolymphocytic leukaemia, two patients with Sézary cell leukaemia, and seven patients with chronic T‐cell lymphocytosis who had a predominance of circulating large granular lymphocytes. Anti‐granulocyte activity was absent in CLL and its variants, but present in the majority of granulocytopenic patients with chronic T‐cell lymphocytosis. In one of these patients, granulocytopenia was associated with complement activating IgG granulocyte antibody. Thus, antibody mediated granulocyte injury appears to be an unusual occurrence in chronic lymphocytic leukaemia, but is a frequent complication of chronic T‐cell lymphocytosis.