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Familial elevation of plasma histidine‐rich glycoprotein in a family with thrombophilia
Author(s) -
Engesser L.,
Kluft C.,
Briët E.,
Brommer E. J. P.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00355.x
Subject(s) - thrombophilia , glycoprotein , histidine , thrombosis , medicine , venous thrombosis , abnormality , family history , myocardial infarction , cardiology , biochemistry , biology , amino acid , psychiatry
Summary A patient with spontaneous venous thrombotic events, myocardial infarction and a positive family history of thrombosis was investigated for underlying disorders of haemostasis. Abnormally high levels of histidine‐rich glycoprotein were found. No other abnormality known or suspected of increasing the risk for thrombosis was present. Elevated levels of histidine‐rich glycoprotein appeared to be present in four other members of the family over two generations suggesting a hereditary disorder. Further study on the relation of elevated histidine‐rich glycoprotein levels and thrombosis is indicated.