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Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes
Author(s) -
Inyang A. L.,
Sodeinde O.,
Okpako D. T.,
Essien E. M.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00331.x-i1
Subject(s) - platelet , plasmodium falciparum , in vitro , secretion , immunology , dense granule , platelet aggregation , thromboxane a2 , malaria , chemistry , biology , biochemistry
Summary An in vitro model for studying the interaction between normal human platelets and Plasmodium falciparum infected erythrocytes in culture is described. After the interaction, changes in platelet function such as enhanced aggregation response to exogenous ADP and increased secretion of dense granule contents were reproduced. Some of these responses represented manifestations of platelet hypersensitivity described earlier in acute malaria infections in man and mice. Preliminary investigations of the mechanisms involved in such reactions revealed that ADP and thromboxane A 2 mechanisms contributed about 79% and 18.5% of the enhanced aggregation response to exogenous stimuli in the system.