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Frequent lymphocytes infection by hepatitis B virus in haemophiliacs
Author(s) -
Lauré F.,
Chatenoud L.,
Pasquinelli C.,
Gazengel C.,
Beaurain G.,
Torchet M.F.,
Zagury D.,
Bach J. F.,
Bréchot C.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00143.x-i1
Subject(s) - hbsag , virology , medicine , immunology , haemophilia , peripheral blood mononuclear cell , lymphocyte , virus , hepatitis b virus , biology , genetics , pediatrics , in vitro
S ummary . We have tested the different mononuclear blood cell populations of seven patients with severe haemophilia and one patient with F VII deficiency for the presence of HBV DNA. These subjects were all polytransfused with non‐heated coagulation factors; three were HBsAg positive, five HBsAg negative but anti‐HBc and anti‐HBs positive; HBV DNA sequences were detected in six subjects including three without detectable serum HBsAg. Furthermore the viral DNA sequences were identified in the T lymphocyte subpopulations (OKT4+ and/or OKT8+ cells). This observation suggests that HBV infection of lymphocytes might be related to the immunological disorders observed in these patients.