Premium
Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with Sjögren syndrome and scleroderma
Author(s) -
RouquetteGally A. M.,
Boyeldieu D.,
Gluckman E.,
Abuaf N.,
Combrisson A.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00141.x-i1
Subject(s) - medicine , scleroderma (fungus) , autoimmunity , bone marrow transplantation , immunology , transplantation , immunopathology , bone marrow , pathology , antibody , inoculation
Summary The occurrence of autoantibodies in 28 long‐term survivors of allogeneic bone marrow transplantation (BMT) (21 with chronic graft‐versus‐host disease) was compared with 48 cases of idiopathic Sjögren syndrome and 82 cases of scleroderma. Antinuclear, anti‐smooth muscle, and anti‐mitochondria antibodies occurred respectively in 80%, 82% and 14% of the post BMT cases. Anti‐native DNA, anti‐soluble nuclear antigen and anticentromere antibodies were not found. Antiepidermal antibodies were present in 14% of the cases but their pathological role is unclear. Although the clinical manifestations of chronic graft‐versus‐host disease are similar to Sjögren syndrome and scleroderma the autoantibody profile is significantly different.