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Molecular analysis of chromosome 22 breakpoints in adult Philadelphia‐positive acute lymphoblastic leukaemia
Author(s) -
Kurzrock Razelle,
Shtalrid Mordechai,
Gutterman Jordan U.,
Koller Charles A.,
Walters Ronald,
Trujillo Jose M.,
Talpaz Moshe
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00055.x
Subject(s) - breakpoint cluster region , breakpoint , chromosomal translocation , philadelphia chromosome , chronic myelogenous leukemia , cytogenetics , chromosome , chromosome 22 , biology , medicine , genetics , cancer research , microbiology and biotechnology , leukemia , gene
S ummary . The Philadelphia (Ph) translocation. t(9;22)(q34:q11). is found in the majority of patients with chronic myelogenous leukaemia (CML) as well as in approximately 20% of adult acute lymphoblastic leukaemia (ALL) patients. The chromosome 22 breakpoint in CML has been localized within a restricted 5.8 kb segment of DNA known as the breakpoint cluster region ( bcr ). To investigate the chromosome 22 breakpoint in ALL. we analysed five adult Ph‐positive ALL patients for bcr rearrangement. Rearrangement was detected within bcr in two patients. However, in one patient the break occurred 5’to the first exon of bcr and in two patients the bcr region was not involved. We conclude that the identical cytogenetic marker, t(9;22), may yield a different genomic configuration in ALL and CML.