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Histological and cytological heterogeneity of bone marrow in Philadelphia‐positive chronic myelogenous leukaemia at diagnosis
Author(s) -
LorandMetze Irene,
Vassallo José,
Souza Carmino A.
Publication year - 1987
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1987.00045.x
Subject(s) - myelofibrosis , bone marrow , medicine , chronic myelogenous leukemia , eosinophil , pathology , blast crisis , biopsy , leukemia , asthma
S ummary . Cytological and histological features of the bone marrow in Philadelphia‐positive chronic myelogenous leukaemia (CML) at diagnosis were analysed in a prospective study. Formerly described (Frisch et al , 1984) subtypes GRAN and GRAN/MEG were found, and myelofibrosis and incipient blast crisis could also be detected. A more or less continuous spectrum of number and degree of atypias in megakaryocytes was found. Biopsy and imprint were complementary in making differential diagnosis of both subtypes. Cytologically, type GRAN/MEG was characterized by a mixed proliferation of neutrophil, eosinophil and basophil series, besides proliferation of megakaryocytes. Type GRAN showed a predominantly neutrophilic proliferation. The importance of performing bone marrow analysis in evaluation of CML patients is discussed.