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Recovery of immurioglobulin isotypes following T‐cell depleted allogeneic bone marrow transplantation
Author(s) -
Brenner M. K.,
Wimperis J. Z.,
Reittie J. E.,
Patterson J.,
Asherson G. L.,
Hoffbrand A. V.,
Prentice H. G.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07580.x
Subject(s) - immunology , transplantation , immunoglobulin e , antibody , medicine , bone marrow , graft versus host disease , bone marrow transplantation , biology
S ummary . After conventional bone marrow transplantation serum IgG, IgM and IgA levels fall from pre‐transplant levels and may not return to normal for 3–12 months. In contrast IgE may rise to supranormal levels, an event that may be associated with graft‐versus‐host disease. We have investigated the recovery of immunoglobulin isotypes in the recipients of allogeneic marrows depleted of T‐cells to prevent graft‐versus‐host disease. We find that pre‐transplant IgG, IgM and IgA levels are maintained throughout the post‐transplant period but that there is a short‐lived rise in IgE about 3 weeks after transplantation: this rise occurs in the absence of clinically detectable graft‐versus‐host disease. We conclude that specific T‐cell depletion does not impair and may actually enhance the functional recovery of B cells after allogeneic BMT.