Premium
Canine platelet alloimmunization: the role of donor selection
Author(s) -
Slichter Sherrill J.,
O'Donnell Margaret R.,
Weiden Paul L.,
Storb Rainer,
Schroeder MariaLouise
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07555.x
Subject(s) - platelet , medicine , platelet transfusion , refractory (planetary science) , immunology , surgery , biology , astrobiology
S ummary Five different platelet transfusion programmes were evaluated in a canine model to determine the most effective method of providing long‐term platelet support. When a weekly transfusion from a single unrelated donor was used, alloimmune platelet refractoriness developed in 95% of recipients after an average of 3.1 ± 0.7 transfusions, and donor platelets circulated for a total of 8.2 ± 2.3 d. When multiple unrelated donors were used, the percentage of refractory recipients was similar (60% versus 77%) whether platelets came from six single donors given sequentially or from a pool of the same six donors given repeatedly. There was, however, a significant difference in the number of transfusions given prior to immunization (14 ± 5 transfusions lasting 32 ± 12 d for sequential single donors as compared to 5.5 ± 1.0 transfusions lasting 13 ± 2 d for the pooled donors).