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Production of anti‐cytomegalovirus antibody following T‐cell depleted bone marrow transplant
Author(s) -
Wimperis J. Z.,
Berry N. J.,
Brenner M. K.,
Grundy J.,
Hoffbrand A. V.,
Griffiths P. D.,
Prentice H. G.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07549.x
Subject(s) - cytomegalovirus , serology , immunology , medicine , antibody , vaccination , transplantation , virology , bone marrow , bone marrow transplant , betaherpesvirinae , bone marrow transplantation , herpesviridae , virus , viral disease
S ummary The serological status to cytomegalovirus (CMV) was examined in 24 patients with no detectable CMV excretion, following T‐iymphocyte depleted bone marrow transplantation. The results show that seropositive recipients continue to produce CMV antibody regardless of the serological status of the donor but that seronegative recipients fail to produce CMV antibody even when the donor is seropositive. These findings suggest that when an effective CMV vaccine becomes available vaccination of the donor would be unlikely to confer protection on the recipient but that vaccination of the recipient may achieve this.