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Anti‐granulocyte opsonic activity and autoimmune neutropenia
Author(s) -
Hadley A. G.,
Holburn A. M.,
BUNCH C.,
CHAPEL H.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07536.x
Subject(s) - opsonin , granulocyte , antibody opsonization , neutropenia , immunology , antibody , monocyte , leukopenia , medicine , chemotherapy
S ummary Sera from patients with unexplained neutropenia have been assayed for anti‐granulocyte opsonic activity using a chemiluminescence technique which measures the metabolic response of human monocytes to antibody‐coated granulocytes. This rapid and simple technique was more sensitive than indirect immunofluorescence in the detection of anti‐granulocyte antibodies.