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Immunohistological localization of factor VIII in placental endothelial cells
Author(s) -
Stel Herbert V.,
Oudejans Cornelis B. M.,
Veerman Enno C. I.,
Meijer Chris J. L. M.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07534.x
Subject(s) - placenta , monoclonal antibody , fetus , antibody , recombinant dna , immunohistochemistry , biology , microbiology and biotechnology , pathology , cancer research , medicine , immunology , pregnancy , gene , genetics
S ummary DNA‐recombinant studies have established that factor VIII‐mRNA is present in liver and placental tissue. In a previous immunohistological study using monoclonal antibodies we have localized factor VIII in liver sinusoidal endothelial cells. In this paper we demonstrate that also the endothelial cells lining the fetal vessels in human placenta contain factor VIII. Based on the combined results of the present study and a previous study we favour‐the concept that factor VIII is synthesized in placental endothelial cells.