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Normal levels of ATP, total nucleotides and activities of three enzymes related to nucleotide metabolism in fetal erythrocytes
Author(s) -
Lestas A. N.,
Nicolaides K. H.,
Rodeck C. H.,
Bellingham A. J.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07523.x
Subject(s) - nucleotide , adenylate kinase , fetus , enzyme , biochemistry , biology , metabolism , chemistry , pregnancy , genetics , gene
S ummary Pure fetal blood was obtained by direct‐vision fetoscopy from 30 fetuses at 17–23 weeks gestation. The erythrocyte concentrations of ATP and total nucleotides and the activities of the enzymes pyrimidine‐5′‐nucleotide nucleosidase (Fyr5N), phosphoribosylpyrophosphate (PRPP) synthetase and adenylate kinase (AK) were analysed by established techniques to find the normal ranges for this gestational age. The ranges were relatively narrow and could serve as reference values for the prenatal diagnosis of defects in nucleotide metabolism.