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Ph 1 negative haematological chimaerism after marrow transplantation in Ph 1 positive chronic granulocytic leukaemia
Author(s) -
Vincent P. C.,
Young G. A. R.,
Singh S.,
Atkinson K.,
Biggs J. C.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07508.x
Subject(s) - bone marrow , chronic granulocytic leukemia , bone marrow transplantation , chimera (genetics) , transplantation , biology , immunology , stem cell , hematology , medicine , leukemia , genetics , gene
S ummary A 17‐year‐old girl with Philadelphia chromosome (Ph 1 ) positive chronic granulocytic leukaemia (CGL) who has undergone two bone marrow transplants from her HLA identical brother is described. Following the second transplant, cytogenetic analysis of her bone marrow cells showed haematological chimaerism with equal numbers of normal male cells and Ph 1 negative female cells indicating the probable eradication of the Ph 1 positive clones with the retention of normal host stem cells.