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Chronic idiopathic and secondary neutropenia: clinical and serological investigations
Author(s) -
Van der Veen J. P. W.,
Hack C. E.,
Engelfriet C. P.,
Pegels J. G.,
Kr. vondem Borne A. E. G.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07506.x
Subject(s) - serology , neutropenia , medicine , immunofluorescence , antibody , indirect immunofluorescence , immunology , gastroenterology , chemotherapy
S ummary Clinical data on 49 patients with chronic idopathic neutropenia (CIN) and 42 patients with neutropenia secondary to a well‐defined immuno‐logical disorder (SN) were collected and related to serological parameters. In 47% of the patients with CIN and 53% of those with SN, a positive direct immunofluorescence test was obtained with granulocytes from the patients. In the sera from the patients in the two groups, antibodies against donor granulocytes were detected by the indirect immunofluorescence test, the leucoagglutination test and/or the granulocytotoxicity test in 15%, 19% and 15%, respectively. The results of the above tests could not be correlated with any clinical or haematological parameter.