Premium
Immunological abnormalities in myelodysplastic syndromes I. SERUM IMMUNOGLOBULINS AND AUTOANTIBODIES
Author(s) -
Mufti G. J.,
Figes Ann,
Hamblin T. J.,
Oscier D. G.,
Copplestoni J. A.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07504.x
Subject(s) - medicine , autoantibody , immunology , antibody , multiple myeloma , immunoelectrophoresis , myelodysplastic syndromes , immunoglobulin m , serum protein electrophoresis , rheumatoid factor , polyclonal antibodies , monoclonal , immunoglobulin g , gastroenterology , bone marrow , monoclonal antibody
S ummary The immunoglobulin levels and autoantibody profiles of 104 patients with primary myelodysplastic syndromes (MDS), classified according to the FAB criteria, were analysed. Eight patients, four with coexistent non‐Hodgkin's lymphomas, three with chronic lymphocytic leukaemia and one with a lymphoplasmacytoma, were excluded from the final analysis of immunoglobulin levels. Serum protein electrophoresis and immunoelectro‐phoresis revealed the presence of monoclonal gammopathy in 12 patients (12·5%). Of the remaining 84 patients, a polyclonal rise in serum immunoglobulins was present in 27 (32%) while a further 16 (19%) had low immunoglobulin levels. The direct antiglobulin test was positive in eight out of 98 patients tested (8·1%), and organ and non‐organ specific autoantibodies were present in 15 out of 67 patients tested (22·3%). Two patients had associated pernicious anaemia (PA), two hypothyroidism, and one PA with hypothyroidism. Three patients had sero‐negative rheumatoid arthritis. These results demonstrate that there is a high incidence of immunological abnormalities in MDS.