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Successful remission induction with deoxycoformycin in elderly patients with T‐helper prolymphocytic leukaemia
Author(s) -
El’Agnaf M. R.,
Ennis K. E.,
Morris T. C. M.,
Robertson J. H.,
Markey Geraldine,
Alexander H. D.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07499.x
Subject(s) - deoxycoformycin , adenosine deaminase , prolymphocytic leukemia , medicine , pentostatin , peripheral blood mononuclear cell , immunology , lymphocyte , gastroenterology , biology , adenosine , in vitro , leukemia , biochemistry , chronic lymphocytic leukemia
S ummary Two elderly patients with prolymphocytic leukaemia (PLL) of T helper phenotype were treated with the adenosine deaminase inhibitor— deoxycoformycin—and achieved remission. The first patient has remained in an unmaintained remission for over a year. The second patient, treated with a regime which produced less side effects, subsequently relapsed in skin and lymph nodes and died. In view of the rarity of this condition a multi‐centre assessment of the effectiveness of deoxycoformycin is indicated. T‐lymphocyte colony formation in both cases was found to be reduced. Co‐culture of the patients’lymphocytes with nonadherent mononuclear cells from normal individuals also showed inhibition of T‐colony formation indicating that lack of nutrients or accessory cells was not responsible for low T‐colony forming capacity.