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T cell‐mediated inhibition of haematopoiesis in aplastic anaemia: serial assay of inhibitory activities of T cells to autologous CFU‐E during immunosuppressive therapy
Author(s) -
Hanada Takashi,
Aoki Yasuko,
Ninomiya Haruhiko,
Abe Tsukasa
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07496.x
Subject(s) - haematopoiesis , aplastic anemia , medicine , immunology , inhibitory postsynaptic potential , cancer research , stem cell , biology , bone marrow , microbiology and biotechnology
S ummary T cell‐mediated inhibition of autologous erythroid colony formation was found in two patients with aplastic anaemia. Each patient was treated separately with ALG and methylprednisolone. Peripheral blood T cells were cryopreserved serially during the course of the disease. The inhibitory activity of T cells was assayed after remission using autologous bone marrow. The inhibitory activity of T cells was lost following the treatment and preceded haematopoietic recovery.