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The haematological puzzle of Hb J Cape Town is partly solved
Author(s) -
Lambridis Alkes J.,
Ramsay Michele,
Jenkins Trefor
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb05561.x
Subject(s) - cape , genetics , gene , homology (biology) , biology , mutation , globin , heterozygote advantage , microbiology and biotechnology , geography , allele , archaeology
Summary. Molecular studies have shown that the mutation giving rise to Hb J Cape Town (α92 arg→gln) is situated on a chromosome from which the other α‐globin gene has been deleted. The −α 3.7 deletion has resulted from crossing‐over within segment I of the Z region of homology. There appears to be an unusually high proportion of the variant haemoglobin in heterozygotes which cannot be explained by gene dosage alone.