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Spontaneous regression of cytogenetic and haematologic anomalies in Ph ‐positive chronic myelogenous leukaemia
Author(s) -
Smadja N.,
Krulik M.,
Audebert A. A.,
Gramont A.,
Debray J.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb05548.x
Subject(s) - trisomy , karyotype , chronic myelogenous leukemia , trisomy 8 , cytogenetics , medicine , philadelphia chromosome , gastroenterology , pathology , oncology , biology , immunology , chromosome , leukemia , chromosomal translocation , genetics , gene
Summary. We report a case of a 27‐year‐old man with Ph 1 ‐positive chronic myelogenous leukaemia (CML). At the time of diagnosis 100% Phpositive cells were found with a trisomy 8 in 50% of them. In absence of therapy, his haematological status remained stable for 3 years. Subsequently a progressive regression of haematologic and cytogenetic data was observed. Eight years after diagnosis the karyotype showed only 37% Ph 1 ‐positive cells and the trisomy 8 had disappeared.