Premium
Lack of pathogenetic role of proteins C and S in thrombosis associated with asparaginase‐prednisone‐vincristine therapy for leukaemia
Author(s) -
Pui ChingHon,
Chesney Carolyn M.,
Bergum Peter W.,
Jackson Carl W.,
Rapaport Samuel I.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb04121.x
Subject(s) - protein s , protein c , asparaginase , antigen , prednisone , medicine , vincristine , thrombosis , factor ix , protein s deficiency , immunology , vitamin , gastroenterology , chemotherapy , leukemia , cyclophosphamide , lymphoblastic leukemia
S ummary . Plasma levels of protein C and protein S antigens were measured in eight children who developed thrombosis following asparaginase‐prednisone‐vincristine treatment for acute lymphoblastic leukaemia and in nine similarly treated children without this complication. Protein C antigen levels were below normal in three of the eight patients with thrombosis and in three of the nine patients without the complication ( P = 0‐38). Low protein S antigen levels were found in five of six patients with thrombosis and in two of seven patients without thrombosis ( P =0‐10). Plasma factor IX and factor X antigen levels, other vitamin K dependent factors, were also measured in the two groups of patients. In general, reduced levels of protein C, protein S or both antigens (anticoagulant vitamin K dependent proteins) were associated with reduced levels of factor IX, factor X, or both of these factors (procoagulant vitamin K dependent clotting proteins). The ratios of protein C and protein S antigens to each other and to factor IX and factor X antigens did not differ between the two groups. Thus, there is no clear evidence that reduced levels of protein C and (or) protein S cause thrombosis in leukaemia patients treated with this drug combination.