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Monoclonal gammopathy with an insulin binding IgG(K) M‐component, associated with severe hypoglycaemia
Author(s) -
Sluiter Wim J.,
Marrink Jan,
Houwen Berend
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb04091.x
Subject(s) - monoclonal gammopathy , medicine , insulin , monoclonal , monoclonal antibody , postprandial , endocrinology , chemotherapy , antibody , immunology
Summary A case is described in which a monoclonal gammopathy was associated with postprandial hypoglycaemia, resulting from insulin binding by the M‐component. The monoclonal immunoglobulin possessed a low affinity for insulin, but its binding capacity was very high. Cytotoxic chemotherapy and diazoxide treatment failed to prevent severe hypoglycaemic attacks.